Mesopartner has assisted national and provincial governments, as well as donor organisations and international organisations, to develop and refine policies, in particular in the field of local and regional economic development. This has included advice on how to frame and implement cluster promotion, how to introduce and connect the topic of "innovation" with the wider field of private sector development, and how to strengthen innovation systems.

Mesopartner is also involved in efforts to re-conceptualise "industrial policy", a topic that has resurfaced in the development discussion in recent years.